Methyltetrazine-DBCO [1802238-48-7]

MedChem Express

Methyltetrazine-DBCO [1802238-48-7]

10

1802238-48-7

Research Use Only

95.22

C34H33N7O7S

683.73

Methyltetrazine-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Methyltetrazine-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

O=S(C(CNC(CCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O)=O)C(NCCCOC4=CC=C(C5=NN=C(C)N=N5)C=C4)=O)(O)=O

-20°C,2°C to 8°C

41115800