MI 63

MedChem Express

MI 63

5

Research Use Only

C29H35Cl2FN4O3

577.52

MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 microM in RH36 cells), and induces apoptosis in ERMS and ARMS[1].

O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@]31C(NC4=C3C=CC(Cl)=C4)=O)NCCN5CCOCC5

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