Mitiperstat

MedChem Express

Mitiperstat [1933460-19-5]

10

1933460-19-5

Research Use Only

99.12

C15H15ClN4OS

334.82

Mitiperstat (AZD4831) is an effective oral inhibitor of myeloperoxidase (MPO). Mitiperstat inhibits MPO and thyroid peroxidase (TPO) with IC50s of 1.5 nM and 0.69 microM. Mitiperstat exhibits a weak inhibitory activity against CYP3A4 with an IC50 of 6 microM. Mitiperstat can reduce inflammation and improve microvascular function, and it can be used in studies related to heart failure, preserved or mildly reduced ejection fraction, non-alcoholic fatty liver disease, and chronic obstructive pulmonary disease[1][2][3][4].

O=C(NC1=S)C(NC=C2)=C2N1CC3=C(C=C(C=C3)Cl)[C@H](N)C

-20°C,2°C to 8°C

12352200