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MK-6186

Research Use Only
HY-167690
MedChem Express
Molecular Weight435.27
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    MK-6186
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Molecular Formula
    C21H12Cl2N6O
  • Molecular Weight
    435.27
  • Scientific Description
    MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with sub-nanomolar activity against wild-type viruses and the two most common NNRTI-resistant RT mutants (K103N and Y181C). MK-6186 exhibits excellent antiviral activity against K103N and Y181C mutant viruses. When MK-6186 targets 12 common NNRTI-associated mutant viruses, only two relatively rare mutants (Y188L and V106I/Y188L) show high resistance, with FC values exceeding 100, while the FC values of the remaining viruses are all below 10. In addition, when MK-6186 faces 96 clinical virus isolates carrying NNRTI-resistant mutations, most (70%) viruses show more than 10-fold resistance to efavirenz (EFV), while only 29% of mutant viruses show more than 10-fold resistance to MK-6186[1].
  • SMILES
    N#CC1=CC(Cl)=CC(OC2=C(C=CC3=C2C=NN3CC4=NNC5=C4C=CC=N5)Cl)=C1
  • UNSPSC
    12352200