MK-8353

Biorbyt

MK-8353 [1184173-73-6]

16

1184173-73-6

Research Use Only

C37H41N9O3S

691.8449

MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK

S(C([H])([H])[H])[C@]1(C(N([H])C2C([H])=C([H])C3=C(C(C4=C([H])N=C(C([H])=C4[H])OC([H])(C([H])([H])[H])C([H])([H])[H])=NN3[H])C=2[H])=O)C([H])([H])N(C([H])([H])C(N2C([H])([H])C([H])=C(C3C([H])=C([H])C(C4N=C([H])N(C([H])([H])[H])N=4)=C([H])C=3[H])C([H])([H])C2([H])[H])=O)C([H])([H])C1([H])[H]

12352200