MK2-IN-3

MedChem Express

MK2-IN-3 [724711-21-1]

10

724711-21-1

Research Use Only

99.70

C21H16N4O

340.38

MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC50 of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC50s=0.21, 0.081, 3.44, 5.7, and >100 microM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC50s>200 microM). MK2-IN-3 can reduce TNFalpha production in both U937 cells and in vivo[1].

O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1

2°C to 8°C

12352200