ML141 --- Cdc42 GTPase Inhibitor

Bioss

ML141 --- Cdc42 GTPase Inhibitor [71203-35-5]

16

Research Use Only

98.0

ML141 is a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase. The EC50 for Cdc42 wild type and Cdc42Q61L mutant were 2.1 and 2.6 microM respectively. It has excellent selectivity for Cdc42 with no inhibition toward Rho and Rac in the same GTPase family, including Rac1, Rab2 and Rab7. In cellular assays ML141 inhibited Cdc42-related filopodia formation and cell migration.

-20°C

51202000