ML252 (hydrochloride)

MedChem Express

ML252 (hydrochloride)

9

Research Use Only

C20H25ClN2O

344.88

ML252 hydrochloride is a selective inhibitor of KCNQ2 (Kv7.2) channel with IC50s of 69 nM, 2.92 microM, 0.12 microM and 0.20 microM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 hydrochloride also inhibits Cytochrome P450 with IC50s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 hydrochloride shows highly brain penetrant[1][2].

CC[C@@H](C1=CC=CC=C1)C(NC2=CC=CC=C2N3CCCC3)=O.Cl

12352200