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MLi-2

MLi-2

T16115
TargetMol Chemicals
CAS Number1627091-47-7
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Product group Chemicals
Molecular Weight379.46
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    MLi-2
  • Delivery Days Customer
    4
  • CAS Number
    1627091-47-7
  • Category Supplier
    Chemical
  • Chemical Name
    MLi-2
  • Molecular Formula
    C21H25N5O2
  • Molecular Weight
    379.46
  • Scientific Description
    MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM).
  • Shelf life instruction
    3 years
  • SMILES
    O(C=1C=C2C(=NNC2=CC1)C=3C=C(N=CN3)N4C[C@H](C)O[C@H](C)C4)C5(C)CC5
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Fell MJ, et al. MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition. J Pharmacol Exp Ther. 2015 Dec;355(3):397-409.
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