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ProductsBack/MLKL antibody [ARC2471]
IHC-P analysis of human esophageal cancer tissue using GTX04592 MLKL antibody [ARC2471]. Antigen retrieval : 10 mM Tris/EDTA buffer pH 9.0 Dilution : 1:100
IHC-P analysis of human esophageal cancer tissue using GTX04592 MLKL antibody [ARC2471]. Antigen retrieval : 10 mM Tris/EDTA buffer pH 9.0 Dilution : 1:100
IHC-P analysis of human esophageal cancer tissue using GTX04592 MLKL antibody [ARC2471]. Antigen retrieval : 10 mM Tris/EDTA buffer pH 9.0 Dilution : 1:100

MLKL antibody [ARC2471]

Research Use Only
GTX04592
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMLKL
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Overview

  • Supplier
    GeneTex
  • Product Name
    MLKL antibody [ARC2471]
  • Delivery Days Customer
    9
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    ARC2471
  • Conjugate
    Unconjugated
  • Gene ID197259
  • Target name
    MLKL
  • Target description
    mixed lineage kinase domain like pseudokinase
  • Target synonyms
    hMLKL; mixed lineage kinase domain-like protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203