WB analysis of mouse liver tissue lysate using GTX66191 MLKL antibody. Dilution : 1:1000 Loading : 25microg per lane
WB analysis of mouse liver tissue lysate using GTX66191 MLKL antibody. Dilution : 1:1000 Loading : 25microg per lane
MLKL antibody - KO/KD Validated
GTX66191
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMlkl
Overview
- SupplierGeneTex
- Product NameMLKL antibody - KO/KD Validated
- Delivery Days Customer9
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID74568
- Target nameMlkl
- Target descriptionmixed lineage kinase domain-like
- Target synonyms9130019I15Rik; mixed lineage kinase domain-like protein
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
- ReactivityHuman, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203