MLS1547

MedChem Express

MLS1547 [315698-36-3]

10

315698-36-3

Research Use Only

99.94

C19H19ClN4O

354.83

MLS1547 is a highly efficacious G protein-biased dopamine D2 receptor (D2R) agonist (Ki=1.2 microM). MLS1547 stimulates D2R G protein-mediated signaling (EC50=0.37 microM in a calcium mobilization assay). MLS1547 acts as an antagonist for dopamine (DA)-stimulated beta-arrestin recruitment to the D2R (IC50=9.9 microM)[1][2].

OC1=C2N=CC=CC2=C(Cl)C=C1CN3CCN(C4=NC=CC=C4)CC3

-20°C,2°C to 8°C

12352200