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MMS21 antibody

Research Use Only
ORB67032
Biorbyt
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetNSMCE2
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Overview

  • Supplier
    Biorbyt
  • Product Name
    MMS21 antibody
  • Delivery Days Customer
    16
  • Applications
    Western Blot
  • Applications Supplier
    WB:1:1000-1:5000 WB
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID286053
  • Target name
    NSMCE2
  • Target description
    NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
  • Target synonyms
    C8orf36; E3 SUMO-protein ligase NSE2; E3 SUMO-protein transferase NSE2; methyl methanesulfonate sensitivity gene 21; MMS21; non-SMC element 2, MMS21 homolog; non-structural maintenance of chromosomes element 2 homolog; NSE2; NSMCE2/PVT1 fusion; PVT1/NSMCE2 fusion; zinc finger, MIZ-type containing 7; ZMIZ7
  • Host
    Rabbit
  • Protein IDQ96MF7
  • Protein Name
    E3 SUMO-protein ligase NSE2
  • Scientific Description
    Rabbit polyclonal to MMS21.MMS21 is also known as E3 SUMO-protein ligase NSE2E3, which is a SUMO-protein ligasecomponent of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks byhomologous recombination. The complex may promote sister chromatid homologous recombinationby recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. MMS21 acts as a E3 ligasemediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesincomponents RAD21 and STAG2. The SUMO protein-ligase activity of MMS21 is required for theprevention of DNA damage-induced apoptosis by facilitating DNA repair.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203