MNK1/2-IN-7

MedChem Express

MNK1/2-IN-7

5

Research Use Only

C31H31N5O2

505.61

MNK1/2-IN-7 (compound 20j) is an orally available inhibitor of MNK1/2 with anticancer activity and hERG safety. MNK1/2-IN-7 also inhibits the phosphorylation of eIF4E, inhibiting the MNK/eIF4E signaling pathway and cancer cell proliferation. MNK1/2-IN-7 is synergistic with Ibrutinib (HY-109970)[1].

O=C(C1=CC=C(C(C=C2)=NN3C2=NC=C3C4=CC5=C(O4)C=CC=C5)C=C1)N6CCC(CC6)N7CCCCC7

12352200