IHC-P analysis of human prostate carcinoma tissue using GTX84103 MOB1B antibody [3G9]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50
![IHC-P analysis of human kidney tissue using GTX84103 MOB1B antibody [3G9]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX84103/GTX84103_2321_IHC-P_w_23061420_881.webp "IHC-P analysis of human kidney tissue using GTX84103 MOB1B antibody [3G9]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![IHC-P analysis of human liver tissue using GTX84103 MOB1B antibody [3G9]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX84103/GTX84103_2322_IHC-P_w_23061420_866.webp "IHC-P analysis of human liver tissue using GTX84103 MOB1B antibody [3G9]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![IHC-P analysis of human prostate tissue using GTX84103 MOB1B antibody [3G9]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX84103/GTX84103_2323_IHC-P_w_23061420_307.webp "IHC-P analysis of human prostate tissue using GTX84103 MOB1B antibody [3G9]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![WB analysis of various cell lines using GTX84103 MOB1B antibody [3G9]. Loading : 35 ug per lane Dilution : 1:200](https://www.genetex.com/upload/website/prouct_img/normal/GTX84103/GTX84103_3492_WB_w_23061420_316.webp "WB analysis of various cell lines using GTX84103 MOB1B antibody [3G9]. Loading : 35 ug per lane Dilution : 1:200")
![WB analysis of HEK293T cells transfected with MOB1B plasmid (Right) or empty vector (Left) for 48 hrs using GTX84103 MOB1B antibody [3G9]. Loading : 5 ug per lane](https://www.genetex.com/upload/website/prouct_img/normal/GTX84103/GTX84103_4126_WB_w_23061420_990.webp "WB analysis of HEK293T cells transfected with MOB1B plasmid (Right) or empty vector (Left) for 48 hrs using GTX84103 MOB1B antibody [3G9]. Loading : 5 ug per lane")
IHC-P analysis of human prostate carcinoma tissue using GTX84103 MOB1B antibody [3G9]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50
MOB1B antibody [3G9] - Overexpression Validated
GTX84103
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityCanine, Human, Monkey, Mouse, Rat
TargetMOB1B
Overview
- SupplierGeneTex
- Product NameMOB1B antibody [3G9] - Overexpression Validated
- Delivery Days Customer9
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID3G9
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID92597
- Target nameMOB1B
- Target descriptionMOB kinase activator 1B
- Target synonymsMATS2; MOB kinase activator 1B; mob1 homolog 1A; MOB1 Mps One Binder homolog B; MOB1, Mps One Binder kinase activator-like 1A; mob1A; MOB4A; MOBKL1A; mps one binder kinase activator-like 1A
- HostMouse
- IsotypeIgG2a
- Scientific DescriptionActivator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
- ReactivityCanine, Human, Monkey, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203