Mouse anti NCAM / CD56
MUB1301P
ApplicationsWestern Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Zebra Fish
TargetNCAM1
Overview
- SupplierNordic-MUbio
- Product NameMouse anti NCAM / CD56
- Delivery Days Customer7
- Antibody Specificity123C3 was defined as a cluster I antibody during the First International Workshop on Small Cell Lung Cancer (SCLC) Antibodies. 123C3 recognizes an epitope in the NCAM exons 11-13 which is dependent on an intact conformation of the first fibronectin type-I
- Application Supplier Note123C3 is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen and paraffin-embedded tissues. Optimal antibody dilution should be determined by titration; recommended range is 1:100 - 1:200 for immunohistochemistry with avidin-biotinylated Horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.
- ApplicationsWestern Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- Applications SupplierImmunocytochemistry;Immunohistochemistry (frozen);Immunohistochemistry (paraffin);Western Blotting
- Category SupplierPrimary antibodies
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID123C3
- Gene ID4684
- Target nameNCAM1
- Target descriptionneural cell adhesion molecule 1
- Target synonymsantigen recognized by monoclonal antibody 5.1H11; CD56; MSK39; NCAM; neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM
- HostMouse
- IsotypeIgG1
- Protein IDP13591
- Protein NameNeural cell adhesion molecule 1
- Source123C3 is a Mouse monoclonal IgG1 antibody derived by fusion of Mouse myeloma cells with spleen cells from a Mouse immunized with the a membrane preparation of a small cell lung carcinoma specimen.
- ReactivityHuman, Zebra Fish
- Reactivity SupplierHuman;Zebrafish
- UNSPSC12352203
References
- 1. Schol, D. J., Mooi, W. J., van der Gugten, A. A., Wagenaar, S. S., and Hilgers, J. (1988). Monoclonal antibody 123C3, identifying small cell carcinoma phenotype in lung tumours, recognizes mainly, but not exclusively, endocrine and neuron-supporting normal tissues, Int J Cancer Suppl 2, 34-40. 2. Mooi, W. J., Wagenaar, S. S., Schol, D., and Hilgers, J. (1988). Monoclonal antibody 123C3 in lung tumour classifiCation. Immunohistology of 358 resected lung tumours, Mol Cell Probes 2, 31-7. 3. Moolenaar, C. E., Muller, E. J., Schol, D. J., Figdor, C. G., Bock, E., Bitter-Suermann, D., and Michalides, R. J. (1990). Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212, Cancer Res 50, 1102-6. 4. Kibbelaar, R. E., Moolenaar, K. E., Michalides, R. J., Van Bodegom, P. C., Vanderschueren, R. G., Wagenaar, S. S., Dingemans, K. P., Bitter-Suermann, D., Dalesio, O., Van Zandwijk, N., and et al. (1991). Neural cell adhesion molecule expression, neuroendocrine differentiation and prognosis in lung carcinoma, Eur J Cancer 27, 431-5. 5. Gerardy-Schahn, R., and Eckhardt, M. (1994). Hot spots of antigenicity in the neural cell adhesion molecule NCAM, Int J Cancer Suppl 8, 38-42. 6. Kwa, H. B., Verhoeven, A. H., Storm, J., van Zandwijk, N., Mooi, W. J., and Hilkens, J. (1995). Radioimmunotherapy of small-cell lung cancer xenografts using 131I- labelled anti-NCAM monoclonal antibody 123C3, Cancer Immunol Immunother 41, 169-74. 7. Kwa, H. B., Verheijen, M. G., Litvinov, S. V., Dijkman, J. H., Mooi, W. J., and Van Krieken, J. H. (1996). Prognostic factors in resected non-small cell lung cancer: an immunohistochemical study of 39 cases, Lung Cancer 16, 35-45.