Mouse KLRG1 Protein (KLR-MM2G1)
KLR-MM2G1
Protein IDO88713
Product group Proteins
Overview
- SupplierKACTUS
- Product NameMouse KLRG1 Protein (KLR-MM2G1)
- Delivery Days Customer9
- CertificationResearch Use Only
- Estimated Purity>95%
- Protein IDO88713
- Protein NameKiller cell lectin-like receptor subfamily G member 1
- Scientific DescriptionImmune homeostasis requires the tight, tissue-specific control of the different CD4 Foxp3 regulatory T (Treg) cell populations. The cadherin-binding inhibitory receptor killer cell lectin-like receptor G1 (KLRG1) is expressed by a subpopulation of Treg cells with GATA3 effector phenotype.Lack of KLRG1 on Treg cells conferred on them a competitive advantage in the gut, but not in lymphoid organs. Hence, although absence of KLRG1 is not enough to increase intestinal Treg cells in KLRG1 knockout mice, KLRG1 ligation reduces T-cell receptor signals and the competitive fitness of individual Treg cells in the intestine.
- Storage Instruction-20°C or -80°C,-80°C
- UNSPSC12352202