Anti-Hu CD137 Purified

EXBIO

Mouse Monoclonal to CD137 / 4-1BB

7

The mouse monoclonal antibody 4B4-1 recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.

Flow cytometry: Recommended dilution: 1-4 microg/ml

Flow Cytometry, ImmunoPrecipitation, ELISA

Research Use Only

4B4-1

1 mg/ml

IgG1

CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.

Human, Primate

2°C to 8°C

12352203