Anti-Hu CD152 Purified Low Endotoxin
12-785
ApplicationsFlow Cytometry, ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman
Overview
- SupplierEXBIO
- Product NameMouse Monoclonal to CD152 / CTLA4
- Delivery Days Customer7
- Antibody SpecificityThe mouse monoclonal antibody BNI3 recognizes an extracellular domain of human CD152 / CTLA4, an approximately 45 kDa type I transmembrane protein serving as a negative regulator of T cell responses.
- Application Supplier NoteFlow cytometry: Recommended dilution: 1-4 microg/ml, Intracellular staining.
- ApplicationsFlow Cytometry, ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- Clone IDBNI3
- Concentration1 mg/ml
- IsotypeIgG2a
- Scientific DescriptionCD152 / CTLA-4 is a homodimeric transmembrane protein similar to CD28 and binding the same ligands, i.e. CD80 (B7.1) and CD86 (B7.2), but with higher affinity. Unlike CD28 with important costimulating functions, CD152 acts as an important inhibitory receptor essential for modulation of the immune system. CD152 / CTLA-4 becomes transiently expressed on activated T cells and its malfunction can cause autoimmune diseases, such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, or thyroid-associated orbitopathy.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203