Anti-Hu CD178 Purified Low Endotoxin

EXBIO

Mouse Monoclonal to CD178 / Fas-L

7

The mouse monoclonal antibody NOK-1 recognizes an extracellular epitope of CD178 / Fas-L, an approximately 40 kDa transmembrane glycoprotein expressed on neutrophils, monocytes, and activated T and NK cells.

Functional application: Blocking. Flow cytometry: Recommended dilution: 1-4 microg/ml

Functional Assay, Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Research Use Only

NOK-1

1 mg/ml

IgG1

CD178 / Fas-L (Fas ligand, CD95L), a member of TNF family transmembrane glycoproteins, is responsible for induction of apoptosis in cells containing its receptor CD95 / Fas. The CD178-mediated apoptosis pathway has been implicated in peripheral tolerance, tissue pathology, and maintenance of the immune privileged sites. Defects in this interaction may be related to some cases of systemic lupus erythematosus (SLE). CD178 was also described as a co-stimulatory receptor for T-cell activation in mice in vivo.

Human

2°C to 8°C

12352203