Anti-Hu CD180 Purified Low Endotoxin

EXBIO

Mouse Monoclonal to CD180

7

The mouse monoclonal antibody G28-8 recognizes an extracellular epitope of CD180, a 95-105 kDa TLR-like glycoprotein expressed on peripheral blood monocytes and dendritic cells, mantle zone B cells and marginal zone B cells, but very weakly on germinal ce

Functional application: Induction of B cell proliferation. Flow cytometry: Recommended dilution: 2 microg/ml.

Functional Assay, Flow Cytometry, ImmunoPrecipitation

Research Use Only

G28-8

1 mg/ml

IgG1

CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1, and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.

Human

2°C to 8°C

12352203