Anti-Hu CD22 Purified

EXBIO

Mouse Monoclonal to CD22

7

The mouse monoclonal antibody S-HCL-1 (also known as S-HCL1) recognizes an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on t

Flow cytometry: Extracellular and intracellular staining; recommended dilution: 1-4 microg/ml. Western blotting: Recommended dilution: 1-2 microg/ml, non-reducing conditions.

Flow Cytometry, Western Blot

Research Use Only

S-HCL-1

1 mg/ml

IgG2b

CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

Human

2°C to 8°C

12352203