Anti-Hu CD255 Purified Low Endotoxin

EXBIO

Mouse Monoclonal to CD255 / TWEAK

7

The mouse monoclonal antibody CARL-1 recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types.

Functional application: Neutralization. Flow cytometry: Recommended dilution: 1-4 microg/ml

Functional Assay, Flow Cytometry, ImmunoHistoChemistry

Research Use Only

CARL-1

1 mg/ml

IgG3

CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3.

Human

2°C to 8°C

12352203