Anti-Hu CD266 Purified Low Endotoxin

EXBIO

Mouse Monoclonal to CD266 / TWEAK R

7

The mouse monoclonal antibody ITEM-4 recognizes an extracellular epitope of CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.

Functional application: Blocking. Flow cytometry: Recommended dilution: 1-4 microg/ml

Functional Assay, Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

ITEM-4

1 mg/ml

IgG2b

CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.

Human, Mouse

2°C to 8°C

12352203