Anti-Hu CD43 Pacific Blue(tm)
PB-220
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
Overview
- SupplierEXBIO
- Product NameMouse Monoclonal to CD43 / Leukosialin
- Delivery Days Customer7
- Antibody SpecificityThe antibody MEM-59 recognizes a neuraminidase-sensitive extracellular epitope on CD43 (Leukosialin), a 95-135 kDa type I transmembrane glycoprotein (mucin-type) which is involved in lymphocyte activation. CD43 is expressed by platelets and at high levels
- Application Supplier NoteFlow cytometry: The reagent is designed for analysis of human blood cells using 4 microl reagent / 100 microl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- Clone IDMEM-59
- ConjugatePacific Blue
- IsotypeIgG1
- Scientific DescriptionCD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumour suppressor p53 protein, but in case of p53 and ARF defficiency CD43 promotes tumour proliferation and viability. It appears to be an important modulator of leukocyte functions.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203