Anti-Hu CD45R0 FITC

EXBIO

Mouse Monoclonal to CD45R0

7

The antibody UCHL1 recognizes an extracellular epitope of CD45R0, a 180 kDa low molecular weight isoform of the leukocyte common antigen (LCA). The antigen is expressed on a subset of memory/activated T cells and on cortical thymocytes.

Flow cytometry: The reagent is designed for analysis of human blood cells using 20 microl reagent / 100 microl of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.

Flow Cytometry

Research Use Only

UCHL1

FITC

IgG2a

CD45R0 is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45R0 is expressed e.g. on macrophages, CD8+ T cells, activated T cells and myeloma cells.

Human

2°C to 8°C

12352203