Anti-Hu CD46 Purified Azide Free

EXBIO

Mouse Monoclonal to CD46 / Membrane Cofactor Protein

7

The antibody MEM-258 recognizes an extracellular epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes,

Flow cytometry: Recommended dilution: 1 microg/ml. Western blotting: Non-reducing conditions.

Flow Cytometry, ImmunoPrecipitation, Western Blot

Research Use Only

MEM-258

1 mg/ml

IgG1

CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.

Bovine, Human

2°C to 8°C

12352203