Anti-Hu CD6 Purified

EXBIO

Mouse Monoclonal to CD6

7

The antibody MEM-98 reacts with an extracellular epitope of CD6, a 100-130 kDa single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells.

Flow cytometry: Recommended dilution: 2 microg/ml. Immunohistochemistry (paraffin sections): Recommended dilution: 10 microg/ml; positive tissue: spleen. Western blotting: Recommended dilution: 1-2 microg/ml; non-reducing conditions.

Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

MEM-98

1 mg/ml

IgG1

CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.

Human

2°C to 8°C

12352203