Anti-Hu CD62L Purified Low Endotoxin

EXBIO

Mouse Monoclonal to CD62L / L-Selectin

7

The mouse monoclonal antibody DREG56 recognizes an extracellular epitope of CD62L / L-selectin, a 65-76 kDa cell surface protein, expressed by neutrophils, monocytes, and subsets of T, B, and NK cells, that interacts with specific carbohydrates exposed on

Functional application: Particularly effective in blocking of lymphocyte CD62L-mediated binding to peripheral lymph node HEV. Flow cytometry: Recommended dilution: 2 microg/ml. Western blotting: Non-reducing conditions.

Functional Assay, Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

DREG56

1 mg/ml

IgG1

CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1).

Human

2°C to 8°C

12352203