Anti-Hu CD84 Purified Low Endotoxin

EXBIO

Mouse Monoclonal to CD84

7

The mouse monoclonal antibody CD84.1.21 recognizes an extracellular epitope of CD84, a single chain cell surface glycoprotein of 64-82 kDa, predominantly expressed B cells, monocytes, platelets and some T cells.

Functional application: Enhancement of CD3-induced IFN-gamma production. Flow cytometry: Recommended dilution: 1-4 microg/ml

Functional Assay, Flow Cytometry, ImmunoPrecipitation

Research Use Only

CD84.1.21

1 mg/ml

IgG2a

CD84 is a highly glycosylated homophilic receptor of SLAM family. It is expressed on platelets and various types of leukocytes, especially following their activation. Ligation of CD84 leads to its phosphorylation on tyrosine residues within the cytoplasmic tail. These docking sites are recognized by downstream signaling molecules, such as phosphatase SHP-2 and adaptor protein SAP/SH2D1A. The function of CD84 has not been fully elucidated yet. Although predominantly activating receptor, its modulating activity was also demonstrated.

Human

2°C to 8°C

12352203