Anti-Hu CD95 Purified Low Endotoxin

EXBIO

Mouse Monoclonal to CD95 / Fas

7

The mouse monoclonal antibody EOS9.1 recognizes an extracellular epitope of CD95 (Fas/APO-1), a 46 kDa glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells.

Functional application: In vitro induction of apoptosis. Flow cytometry: Recommended dilution: 2-6 microg/ml.

Functional Assay, Flow Cytometry

Research Use Only

EOS9.1

1 mg/ml

IgM

CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.

Human

2°C to 8°C

12352203