Anti-CDK1 Purified

EXBIO

Mouse Monoclonal to Cdk1 / p34Cdc2

7

The antibody POH-1 specifically detects Cdk1 (p34Cdc2; an intracellular antigen). Staining of Cdk1 reflects the proliferating potential of respective tissue.

Immunohistochemistry (paraffin sections): Recommended dilution: 10 microg/ml; positive tissue: thymus. Western blotting: Recommended dilution: 1-2 microg/ml.

ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

POH-1

1 mg/ml

IgG2a

Cdk1 (cyclin-dependent kinase 1), also known as p34Cdc2 (cell division control protein kinase 2) depends on cyclin A and B and is triggered by a positive feedback loop at the end of G2 phase, which is the key event that initiates mitotic entry. Destruction of cyclin B during metaphase results in inactivation of Cdk1, allowing mitotic exit and cell division. Cdk1 also contributes to the control of DNA replication. Cdk1 can be ihibited by several transcriptional targets of p53, such as p21WAF.

Bovine, Drosophila, Human, Mouse, Primate, Rat, Xenopus

2°C to 8°C

12352203