Anti-FoxP3 Alexa Fluor(r) 647

EXBIO

Mouse Monoclonal to FoxP3

7

The mouse monoclonal antibody 3G3 recognizes N-terminal region of FoxP3, a 47-55 kDa transcription factor (intracellular antigen), which is the master regulator in the development and function of regulatory T cells.

Flow cytometry: Recommended dilution: 1-5 microg/ml. Intracellular staining.

Flow Cytometry, Western Blot

Research Use Only

3G3

0.5 mg/ml

AlexaFluor 647

IgG1

FoxP3 (forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome.

Human, Mouse

2°C to 8°C

12352203