Mozavaptan

MedChem Express

Mozavaptan [137975-06-5]

10

137975-06-5

Research Use Only

99.71

C27H29N3O2

427.54

Mozavaptan (OPC-31260) is a benzazepine derivative and a potent, selective, competitive and orally active vasopressin V 2 receptor antagonist with an IC 50 of 14 nM. Mozavaptan shows ~85-fold selectivity for V 2 receptor over V 1 receptor (IC 50 of 1.2 microM), and can antagonize the antidiuretic action of arginine vasopressin (AVP) in vivo. Mozavaptan has the potential for hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), and congestive heart failure treatment [1] [2] .

CC1=CC=CC=C1C(NC2=CC=C(C(N3C(C=CC=C4)=C4C(N(C)C)CCC3)=O)C=C2)=O

-20°C,2°C to 8°C

12352200