mPGES1-IN-3

MedChem Express

mPGES1-IN-3 [1469976-70-2]

10

1469976-70-2

Research Use Only

C24H16ClF5N4O3

538.85

mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 ( mPGES-1 ) inhibitor, which exhibits excellent mPGES-1 enzyme ( IC 50 : 8 nM), cell (A549 IC 50 : 16.24 nM) and human whole blood potency (IC 50 : 249.9 nM) [1] .

O=C(NC1=CC(F)=CC(C(F)(F)F)=C1)C2=C(OCCO3)C3=C(N(C)C(NC4=C(Cl)C=CC=C4F)=N5)C5=C2

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