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Mpro [3CLpro] (SARS-CoV-2) (rec.) (His)

Research Use Only
SBB-DE0129
South Bay Bio
Protein IDP0C6U8
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    South Bay Bio
  • Product Name
    Mpro [3CLpro] (SARS-CoV-2) (rec.) (His)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Formulation
    Liquid
  • Protein IDP0C6U8
  • Protein Name
    Replicase polyprotein 1a
  • Scientific Description
    3CLpro recognizes the peptide sequence LQ[S/A/G] where it cleaves c-terminal to the amino acid glutamine (use product SBB-PS0130, KTSAVLQ-Rh110-Glu as universal substrate). The protease 3CLpro is a potential drug target for coronavirus infections due to its essential role in processing the polyproteins that are translated from the viral RNA. The X-ray structures of the unliganded SARS-CoV-2 protease 3CLpro and its complex with an alpha-ketoamide inhibitor provides a basis for design of alpha-ketoamide inhibitors. This SARS Coronavirus recombinant 3CLpro is N-terminally His10-tagged and expressed in E.coli. - Recombinant Protein. Mpro (Papain-like Protease) (aa 1540-1841) is fused at the N-terminus to a His-tag.. Source: E. coli. Liquid. In 50mM HEPES pH 7.5, 100mM NaCl, 1mM TCEP. 3CLpro recognizes the peptide sequence LQ[S/A/G] where it cleaves c-terminal to the amino acid glutamine (use product SBB-PS0130, KTSAVLQ-Rh110-Glu as universal substrate). The protease 3CLpro is a potential drug target for coronavirus infections due to its essential role in processing the polyproteins that are translated from the viral RNA. The X-ray structures of the unliganded SARS-CoV-2 protease 3CLpro and its complex with an alpha-ketoamide inhibitor provides a basis for design of alpha-ketoamide inhibitors. This SARS Coronavirus recombinant 3CLpro is N-terminally His10-tagged and expressed in E.coli.
  • Storage Instruction
    -80°C
  • UNSPSC
    12352202

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