STING antibody

GeneTex

MPYS antibody

9

WB: 1 microg/mL. ICC/IF: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

1 mg/ml

Liquid

STING1

stimulator of interferon response cGAMP interactor 1

endoplasmic reticulum IFN stimulator; endoplasmic reticulum interferon stimulator; ERIS; hMITA; hSTING; MITA; mitochondrial mediator of IRF3 activation; MPYS; NET23; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; SAVI; stimulator of interferon genes protein; stimulator of interferon protein; STING; STING-beta; TMEM173; transmembrane protein 173

Stimulator of interferon genes protein

MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.

-20°C or -80°C,2°C to 8°C

12352203