Navlimetostat

MedChem Express

MRTX-1719 [2630904-45-7]

5

2630904-45-7

Research Use Only

99.40

C23H18ClFN6O2

464.88

Navlimetostat is a potent, orally active, selective PRMT5 MTA complex inhibitor, with IC 50 of 3.6 and 20.5 nM for PRMT5 MTA and PRMT5 . Navlimetostat binds to the PRMT5 MTA complex, with KD value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo , and can be used for cancer study [1] [2] .

FC1=C(C=C(C(C#N)=[C@]1[C@]2=C(C3=CC=C4C(C(CN)=NNC4=O)=C3)C=NN2C)OC5CC5)Cl

-20°C,2°C to 8°C

12352200