Navlimetostat

MedChem Express

MRTX-1719 [2630904-45-7]

5

2630904-45-7

Research Use Only

99.40

C23H18ClFN6O2

464.88

Navlimetostat is a potent, orally active, selective PRMT5 MTA complex inhibitor, with IC50 of 3.6 and 20.5 nM for PRMT5 MTA and PRMT5. Navlimetostat binds to the PRMT5 MTA complex, with KD value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo, and can be used for cancer study[1][2].

FC1=C(C=C(C(C#N)=[C@]1[C@]2=C(C3=CC=C4C(C(CN)=NNC4=O)=C3)C=NN2C)OC5CC5)Cl

-20°C,2°C to 8°C

12352200