Navlimetostat [2630904-45-7]

MedChem Express

Navlimetostat [2630904-45-7]

5

2630904-45-7

Research Use Only

99.40

C23H18ClFN6O2

464.88

Navlimetostat is a potent, orally active, selective PRMT5-MTA complex inhibitor, with IC50 of 3.6 and 20.5 nM for PRMT5-MTA and PRMT5. Navlimetostat binds to the PRMT5-MTA complex, with KD value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo, and can be used for cancer study[1][2].

FC1=C(C=C(C(C#N)=[C@]1[C@]2=C(C3=CC=C4C(C(CN)=NNC4=O)=C3)C=NN2C)OC5CC5)Cl

-20°C,2°C to 8°C

12352200