MRVI1 antibody

GeneTex

MRVI1 antibody

9

WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

IRAG1

inositol 1,4,5-triphosphate receptor associated 1

IRAG, JAW1L, MRVI1, inositol 1,4,5-triphosphate receptor associated 1, IP3R-associated cGMP kinase substrate, JAW1-related protein MRVI1, inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate, inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate, murine retrovirus integration site 1 homolog

Rabbit

IgG

Inositol 1,4,5-triphosphate receptor associated 1

This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, few of which initiate translation at a non-AUG (CUG) start site. [provided by RefSeq]

Human

-20°C or -80°C,2°C to 8°C

41116161