MS33

MedChem Express

MS33 [2407449-11-8]

10

2407449-11-8

Research Use Only

C64H84F3N11O7S

1208.48

MS33 is a potent WDR5 degrader, with K d s of 870 nM and 120 nM for VCB and WDR5 , respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia [1] [2] [3] .

CN(CC1)CCN1C(C(NC(C2=CNC(C=C2C(F)(F)F)=O)=O)=C3)=CC=C3C4=CC(CN5CCN(CCNC(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N6C[C@H](O)C[C@H]6C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)=O)=O)CC5)=CC=C4

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