MS934 [2756323-15-4]

MedChem Express

MS934 [2756323-15-4]

14

2756323-15-4

Research Use Only

98.48

C52H69F3IN7O6S

1104.11

MS934 is a novel improved VHL-recruiting MEK 1/2 PROTAC degrader. MS934 also degrades CRAF. MS934 can be used for the research of variety of human cancers, such as melanoma, nonsmall cell lung cancer (NSCLC), colorectal cancer, primary brain tumors, and hepatocellular carcinoma (Pink: Target protein ligand (HY-168288); Black: linker (HY-168289); Blue: E3 ligase ligand (HY-112078))[1][2][3].

O=C(C1=C(C(F)=C(C=C1)F)NC2=C(C=C(C=C2)I)F)NOCCCCNCCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C5=C(N=CS5)C)C=C4)C)=O)=O)=O

-20°C

12352200