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ProductsBack/MTEP [329205-68-7]
Chemical Structure
Chemical Structure
Chemical Structure

MTEP [329205-68-7]

Research Use Only
AG-CR1-0022
AdipoGen Life Sciences
CAS Number329205-68-7
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight200.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    MTEP [329205-68-7]
  • Delivery Days Customer
    10
  • CAS Number
    329205-68-7
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C11H8N2S
  • Molecular Weight
    200.3
  • Scientific Description
    Chemical. CAS: 329205-68-7. Formula: C11H8N2S. MW: 200.3. Potent and selective antagonist for mGluR5. 5-fold higher anxiolytic activity than MPEP. Antidepressant. Neuroprotective. Produces antiparkinsonian-like effects in rats. - Potent and selective antagonist for mGluR5 [1, 2]. 5-fold higher anxiolytic activity than MPEP [3]. Antidepressant [4]. Neuroprotective [5]. Produces antiparkinsonian-like effects in rats [6].
  • SMILES
    CC1=NC(=CS1)C#CC1=CC=CN=C1
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

References

  • 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity: J. Med. Chem. 46 204 (2003)
  • Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling: A. Klodzinska, et al.; Neuropharmacology 47, 342 (2004)
  • Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP: P.M. Lea IV & A.I. Faden; CNS Drug Rev. 12, 149 (2006)
  • Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist: A. Palucha, et al.; Pharmacol. Biochem. Behav. 81, 901 (2005)
  • Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors: P.M.t. Lea, et al.; Br. J. Pharmacol. 145, 527 (2005)
  • MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats: K. Ossowska, et al.; Neuropharmacology 49, 447 (2005)