MTF1(MTF1/2649), CF594 conjugate, 0.1mg/mL [26628-22-8]

Biotium

MTF1(MTF1/2649), CF594 conjugate, 0.1mg/mL

9

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

MTF1/2649

0.1 mg/ml

Other Conjugate

MTF1

metal regulatory transcription factor 1

metal regulatory transcription factor 1; metal-responsive transcription factor 1; MRE-binding transcription factor; MRE-binding transcription factor-1; MTF-1; transcription factor MTF-1; zinc regulatory factor; ZRF

Mouse

IgG1

Metal regulatory transcription factor 1

The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse

2°C to 8°C

12352203