MTX115325

MedChem Express

MTX115325

14

Research Use Only

99.08

C18H16N6O2

348.36

MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC 50 =12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC 50 =32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine [1] .

O=C(C1=NC=C(C2=CC=NC(C#N)=C2)O1)N3[C@]4([H])[C@@](CC3)([H])[C@H](N(C4)C#N)C

-20°C

12352200