Mu opioid receptor antagonist 1

MedChem Express

Mu opioid receptor antagonist 1

10

Research Use Only

C24H28N4O4

436.50

Mu opioid receptor antagonist 1 (compound 19) is a selective and orally active micro opioid receptor (MOR) ligand with an K i value of 0.58 nM and an EC 50 of 1.15 nM. Orally administrating with Mu opioid receptor antagonist 1 increases intestinal motility during morphine-induced constipation. Mu opioid receptor antagonist 1 can be used for researching opioid-induced constipation (OIC) [1] .

O[C@]12[C@H]3CC4=C5[C@@]1(CCN3CC6CC6)[C@H]([C@@H](CC2)NC(C7=CN=CN7)=O)OC5=C(O)C=C4

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