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MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC041007
Biotium
ApplicationsWestern Blot, RadioImmunoAssay
Product group Antibodies
ReactivityBovine, Feline, Human, Monkey, Mouse
TargetMUC5AC
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Overview

  • Supplier
    Biotium
  • Product Name
    MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    Western Blot, RadioImmunoAssay
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2-11M1
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID4586
  • Target name
    MUC5AC
  • Target description
    mucin 5AC, oligomeric mucus/gel-forming
  • Target synonyms
    gastric mucin; leB; lewis B blood group antigen; major airway glycoprotein; MUC5; mucin; mucin 5, subtypes A and C, tracheobronchial/gastric; mucin 5AC, oligomeric mucus/gel-forming pseudogene; mucin-5 subtype AC, tracheobronchial; mucin-5AC; TBM; tracheobronchial mucin
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP98088
  • Protein Name
    Mucin-5AC
  • Scientific Description
    This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC). Its epitope is located in the N-terminal cysteine rich part of the peptide core of MUC5AC, which is heavily glycosylated. Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. MAb 2-11M1 reacts with the protein backbone exclusively; it only reacts with fully deglycosylated MUC5AC. Therefore, the material under test should also be fully deglycosylated. This can be achieved with standard periodate oxidation method. The success of the deglycosylation can be checked with routine PAS (Periodic Acid Shiff) staining. After deglycosylation, the preparation should no longer be stainable with PAS reagent. Only then 2-11M1 will react should MUC5AC be present. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.
  • Source
    Animal
  • Reactivity
    Bovine, Feline, Human, Monkey, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203