Mutant IDH1-IN-6 [2230263-60-0]

TargetMol Chemicals

Mutant IDH1-IN-6 [2230263-60-0]

999

2230263-60-0

Chemical

Research Use Only

Mutant IDH1-IN-6

C28H36N6O3

504.635

Mutant IDH1-IN-6 is an orally active compound that effectively inhibits mutant isocitrate dehydrogenase (IDH) enzymes. It demonstrates potency and selectivity, with IC50 values of 6.27, 3.71, 36.9, and 11.5 nM for IDH1 R132H, IDH1 R132C, IDH2 R140Q, and IDH2 R172K mutants, respectively. Notably, Mutant IDH1-IN-6 exhibits lower activity in inhibiting wild-type IDH enzymes.

3 years

CCN1C(=O)OCc2cnc(N[C@@H](C)c3ccc(cc3)[C@H](CC3CC3)N3CCN(CC3)C(=O)C=C)nc12

-20°C

51202000