Mutant IDH1/NAMPT-IN-1

MedChem Express

Mutant IDH1/NAMPT-IN-1 [3040122-14-0]

5

Research Use Only

C30H29FN6O4

556.59

Mutant IDH1/NAMPT-IN-1 (Compound 23h) is a dual inhibitor of mutant isocitrate dehydrogenase 1 (mutant IDH1) (IC50=14.93 nM) and nicotinamide phosphoribosyltransferase (NAMPT) (IC50=12.56 nM). Mutant IDH1/NAMPT-IN-1 can induce apoptosis. Mutant IDH1/NAMPT-IN-1 crosses the blood-brain barrier effectively[1].

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