MY-1B

MedChem Express

MY-1B

5

Research Use Only

99.94

C22H18BrN3O2

436.30

MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 ( IC 50 : 1.3 microM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2 . MY-1B can stereoselectively and covalently bind to PSME1 , disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes [1] [2] [3] .

O=C([C@H]1[C@@H](C2=CC=C(C=C2)Br)CN1C(C=C)=O)NC3=CC=CC4=C3N=CC=C4

2°C to 8°C

12352200