MYOG / Myogenin Antibody (clone MGN185)

LifeSpan BioSciences

MYOG / Myogenin Antibody (clone MGN185)

23

Human MYOG / Myogenin

Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Myogenin antibody labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilms tumor. ELISA: Order BSA-free antibody format for coating.. ELISA, Flo (0.5 - 1 µg/10E6 cells), IF (1 - 2 µg/ml), IHC, IHC-P (0.5 - 1 µg/ml), IP, WB (0.5 - 1 µg/ml) Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Myogenin antibody labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilms tumor. ELISA: Order BSA-free antibody format for coating.

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

MGN185

0.2 mg/ml

Unconjugated

...

MYOG

myogenin

bHLHc3; class C basic helix-loop-helix protein 3; MYF4; myf-4; myogenic factor 4; myogenin

Mouse

IgG1

Feline, Human, Mouse, Porcine, Rat

2°C to 8°C

12352203